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Caudatin induced ubiquitin (Ub)-dependent glucocorticoid receptor (GR) degradation and blocked subsequent Of course-connected protein (YAP) nuclear accumulation and concentrate on gene transcription indicators in BCSCs. These effects clearly show the GR/YAP signaling pathway regulates BCSC development Which caudatin may be a possible chemopreventiv
Bars signifies imply ± S.D. from one particular experiment from two comparing littermates. A single-way ANOVA followed by Tukey’s test numerous comparisons take a look at was utilized for statistical Examination. c IHC was carried out for MMP13, with arrows pointing to examples of stained chondrocytes. Agent visuals are shown with pixel inte